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CALQUENCE® (acalabrutinib) Long-Term Data – Dr Brem, MD

Please see Full Prescribing Information: https://bit.ly/3Ly3ru0

This video is intended for US healthcare professionals only.

 

Elizabeth Brem, MD, discusses CALQUENCE efficacy and safety results in chronic lymphocytic leukemia (CLL)patients, including long-term follow-up data and her personal experience treating patients with CLL. Topics include the overview and results of ELEVATE-TN, ASCEND and ELEVATE-RR phase 3 trials.

 

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Serious adverse events, including fatal events, have occurred with CALQUENCE, including serious and opportunistic infections, hemorrhage, cytopenias, second primary malignancies, cardiac arrhythmias, and hepatotoxicity, including drug-induced liver injury. The most common adverse reactions (≥30%) are diarrhea, upper respiratory tract infection, headache, musculoskeletal pain, lower respiratory tract infection, and fatigue. The most common Grade 3 or 4 laboratory abnormalities (≥10%) are absolute neutrophil count decreased, absolute lymphocyte count decreased, platelets decreased, and hemoglobin decreased.

 

 

 

CALQUENCE® (acalabrutinib) Safety Data – Dr Levy, MD


This video is intended for US healthcare professionals only.

 

Yair Levy, MD emphasizes the importance of cardiovascular risks in chronic lymphocytic leukemia (CLL) patients and discusses CALQUENCE safety profile, including select cardiovascular safety data. Topics include the overview and results of ELEVATE-TN, ASCEND and ELEVATE-RR phase 3 trials, including select cardiovascular safety data and discontinuation rates.

 

Select Safety Information

Serious adverse events, including fatal events, have occurred with CALQUENCE, including serious and opportunistic infections, hemorrhage, cytopenias, second primary malignancies, cardiac arrhythmias, and hepatotoxicity, including drug-induced liver injury. The most common adverse reactions (≥30%) are diarrhea, upper respiratory tract infection, headache, musculoskeletal pain, lower respiratory tract infection, and fatigue. The most common Grade 3 or 4 laboratory abnormalities (≥10%) are absolute neutrophil count decreased, absolute lymphocyte count decreased, platelets decreased, and hemoglobin decreased.

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