Oncology

Relapsed/Refractory Multiple Myeloma

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Expert Roundtables Podcast: Salvage Therapy After BCMA-Directed Chimeric Antigen Receptor T-Cell Therapy in Relapsed/Refractory Multiple Myeloma

expert roundtables by Ajai Chari, MD; Joseph Mikhael, MD, MEd, FRCPC, FACP, FASCO; Robert Z. Orlowski, MD, PhD
Overview

The rapidly expanding treatment landscape for relapsed/refractory multiple myeloma has created new opportunities and challenges for managing relapse after BCMA-directed CAR T-cell therapy. As noted by our experts in today’s podcast, selecting the most appropriate salvage therapy depends on several factors, including prior BCMA-directed treatment as well as disease and patient characteristics.

 

References

Costa LJ, Banerjee R, Mian H, et al. International Myeloma Working Group Immunotherapy Committee recommendation on sequencing immunotherapy for treatment of multiple myeloma. Leukemia. 2025;39(3):543-554. doi:10.1038/s41375-024-02482-6

 

Dima D, Banerjee R, Hansen DK. CAR T-cell therapy and bispecific antibodies in the management of multiple myeloma. Hematology Am Soc Hematol Educ Program. 2025;2025(1):324-333. doi:10.1182/hematology.2025000721

 

Martino EA, Vigna E, Bruzzese A, et al. Selinexor in multiple myeloma. Expert Opin Pharmacother. 2024;25(4):421-434. doi:10.1080/14656566.2024.2333376

 

Min C, Zhong X, Cui Y, Zhang H, Wang Q. Strategies for salvage therapy post CAR-T therapy failure in refractory/relapsed multiple myeloma patients. Front Pharmacol. 2025;16:1515555. doi:10.3389/fphar.2025.1515555

 

Wang S, Li W, Li J, Guo Z, Chen J, Hu Z. Antigen escape in CAR-T therapy: a tumor microenvironment perspective from hematological to solid tumors. Int J Cancer. 2026;158(4):835-846. doi:10.1002/ijc.70117

Ajai Chari, MD

Professor of Clinical Medicine
Director, Multiple Myeloma Program
UCSF Helen Diller Family Comprehensive Cancer Center
University of California, San Francisco
San Francisco, CA

Joseph Mikhael, MD, MEd, FRCPC, FACP, FASCO

Professor, Clinical Genomics and Therapeutics
Translational Genomics Research Institute (TGen)
City of Hope Comprehensive Cancer Center
Consultant Hematologist and Director, Myeloma Research
HonorHealth Research Institute
Scottsdale, AZ

Robert Z. Orlowski, MD, PhD

Florence Maude Thomas Cancer Research Professor
Vice Chair, Myeloma Translational Research
Deputy Chair, Department of Lymphoma/Myeloma
Professor, Department of Experimental Therapeutics
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX

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