Allergy & Immunology

Chronic Spontaneous Urticaria

Expert Roundtables Podcast: Optimizing the Diagnosis and Treatment of Chronic Spontaneous Urticaria

expert roundtables by Thomas B. Casale, MD; Allen P. Kaplan, MD; Giselle S. Mosnaim, MD, MS

Overview

Presently, several targeted therapies are available for chronic spontaneous urticaria (CSU) when second-generation nonsedating H₁ antihistamines fail, including oral and subcutaneous options. In this CSU podcast, our featured experts explain how, despite these advancements, gaps in CSU care persist, particularly within primary care. This underscores the need for timely referral to an allergist/immunologist or dermatologist to ensure appropriate diagnosis and treatment of the disease.

References

AAAAI/ACAAI JTF Chronic Urticaria Guideline Panel. Chronic urticaria guidelines: 2026 AAAAI/ACAAI Joint Task Force (JTF) on Practice Parameters GRADE- and Institute of Medicine-based recommendations. Updated June 9, 2026. Accessed September 15, 2026. https://college.acaai.org/wp-content/uploads/2026/06/JTF-CU_guideline-2026-06-01-For-Distribution.pdf

Ansotegui IJ, Bousquet J, Canonica GW, et al. Why fexofenadine is considered as a truly non-sedating antihistamine with no brain penetration: a systematic review. Curr Med Res Opin. 2024;40(8):1297-1309. doi:10.1080/03007995.2024.2378172

Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734-766. doi:10.1111/all.15090

Profile

Thomas B. Casale, MD

Professor of Medicine and Pediatrics
Chief of Clinical and Translational Research
Division of Allergy and Immunology
University of South Florida
Tampa, FL

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Allen P. Kaplan, MD

Professor

Department of Medicine

Medical University of South Carolina

Charleston, SC

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Giselle S. Mosnaim, MD, MS

Director, Allergy and Immunology Research
Director, Early Investigator Career Development Program
Director, Urticaria Center of Reference and Excellence (UCARE)
Endeavor Health Department of Medicine
Evanston, IL
Clinical Professor of Medicine
The University of Chicago Pritzker School of Medicine
Chicago, IL