Tuberous Sclerosis Complex


Expert Perspectives in Tuberous Sclerosis Complex to Cover Key Topics in Tuberous Sclerosis Complex Treatment

expert perspectives by David N. Franz, MD; Elizabeth A. Thiele, MD, PhD; Gary W. Mathern, MD


Expert Perspectives delivers health care providers with insights from key thought leaders on the latest advancements and current practices in medicine, in a concise and timely format. This issue of Expert Perspectives in Tuberous Sclerosis Complex will feature selected topics in Tuberous Sclerosis Complex that we hope you will find of value in your clinical practice.


Expert Roundtables

  • Role of Mechanistic Target of Rapamycin Inhibitors in the Treatment of Tuberous Sclerosis ComplexAssociated Epilepsy
  • Epilepsy Management in Tuberous Sclerosis Complex: Existing and Evolving Therapies
  • Current Concepts for Multidisciplinary Care in Tuberous Sclerosis Complex
  • Importance of Seizure Control in Tuberous Sclerosis Complex

Clinical Topic Updates

  • Long-term Outcomes of Resective Surgery for Intractable Epilepsy in Tuberous Sclerosis Complex
  • Importance of Early Diagnosis of Tuberous Sclerosis Complex
  • Pathogenic Variants Predictive of Severe Clinical Manifestations of Tuberous Sclerosis Complex in Infants
  • Morbidity and Mortality Associated With Neurological/Neuropsychiatric Aspects of Tuberous Sclerosis Complex

Patient Care Perspectives

  • Influence of Seizures on Developmental Outcomes in Tuberous Sclerosis Complex
  • Quality of Life in Adults With Tuberous Sclerosis Complex and Their Caregivers
  • Tools for Helping Patients and Families With Rare Diseases
  • Quality of Life in Children and Adolescents With Tuberous Sclerosis Complex

David N. Franz, MD

Professor of Pediatrics and Neurology
Associate Director of Clinical Affairs, Division of Neurology
University of Cincinnati College of Medicine
Founding Director, Tuberous Sclerosis Clinic
Cincinnati Children’s Hospital Medical Center
Cincinnati, OH

Elizabeth A. Thiele, MD, PhD

Director, Pediatric Epilepsy Program
Director, Carol and James Herscot Center for Tuberous Sclerosis Complex
Director, Dravet Syndrome Comprehensive Clinical Program
Massachusetts General Hospital
Professor of Neurology
Harvard Medical School
Boston, MA

Gary W. Mathern, MD

Professor In-Residence, Departments of Neurosurgery and Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine at UCLA
Dr. Alfonsina Q. Davies Endowed Chair in Honor of Paul Crandall, M.D. for Epilepsy Research
Codirector, Adult Epilepsy Surgery and Pediatric Epilepsy Surgery Programs
University of California, Los Angeles
Los Angeles, CA