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Ronald P. DeMatteo, MD, FACS

John Rhea Barton Professor and Chair
Department of Surgery
Perelman School of Medicine at the University of Pennsylvania
Philadelphia, PA

Ronald P. DeMatteo, MD, FACS, is the John Rhea Barton Professor and chair of the Department of Surgery at the Perelman School of Medicine at the University of Pennsylvania. His academic training includes a BA from Johns Hopkins University and an MD from Weill Cornell Medical College. Dr DeMatteo completed his general surgery residency at the Hospital of the University of Pennsylvania and a surgical oncology fellowship at Memorial Sloan Kettering Cancer Center (MSK). He was the vice chair of surgery at MSK from 2006 to 2017 and the fellowship director at MSK for 7 years.


He is an expert surgical oncologist specializing in treating diseases of the liver, bile duct, gallbladder, and pancreas, as well as abdominal sarcomas. His clinical research focuses on cancers of the liver, bile duct, gallbladder, and pancreas. Dr DeMatteo has spent 25 years studying gastrointestinal stromal tumors (GIST), which are soft tissue tumors of the GI tract and the most common human sarcoma. He led the 3 national trials testing the benefits of imatinib mesylate following surgery for GIST, including the American College of Surgeons Oncology Group Z9001 (Alliance) study that led to the US Food and Drug Administration approval of adjuvant imatinib. He has been continuously funded by the National Institutes of Health (NIH) for more than 20 years. Previously, he was chair of the NIH Cancer Immunopathology and Immunotherapy (CII) study section.


Dr DeMatteo has trained more than 40 individuals in his laboratory and more than 100 clinical fellows. He has 450 scientific publications, including articles in Nature Medicine, The Lancet, the Journal of Clinical Investigation, and the Journal of Experimental Medicine. He is president-elect of the Society of Surgical Oncology and a member of the National Academy of Medicine, The American Society for Clinical Investigation, the Association of American Physicians, and the Society of Clinical Surgery.


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