Psychiatry
Major Depressive Disorder
Patient Care Perspectives Podcast: Structured Antidepressant Tapering and Support
Structured antidepressant tapering for patients with depression requires an evaluation of multiple factors, including the reason for ending treatment. Tapering a drug that never worked or that caused intolerable side effects is usually straightforward. However, tapering an antidepressant after months of successful treatment must occur more carefully to avoid discontinuation-related symptoms. In today’s podcast, Michael E. Thase, MD, discusses important clinical contexts and practical considerations when tapering antidepressants.
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Zaccoletti D, Mosconi C, Gastaldon C, et al. Comparison of antidepressant deprescribing strategies in individuals with clinically remitted depression: a systematic review and network meta-analysis. Lancet Psychiatry. 2026;13(1):24-36. doi:10.1016/S2215-0366(25)00330-X
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