Ophthalmology
Wet AMD
Conference Reporter® Podcast: Clinical Trial Updates—Platforms, Genes, and Pathways in Wet Age-Related Macular Degeneration
Frequent intravitreal anti-VEGF therapy has transformed outcomes in wet age-related macular degeneration, but treatment burden and undertreatment remain important challenges. In today’s podcast, Rishi P. Singh, MD, FASRS, reviews sustained delivery approaches, gene therapy, TKIs, and emerging pathways based on clinical trial updates presented at the AAO 2026 Annual Meeting.
Following these presentations, featured expert Rishi P. Singh, MD, FASRS, was interviewed by Conference Reporter Editor-in-Chief Tom Iarocci, MD. Clinical perspectives from Dr Singh on these findings are presented here.
Acharya N. Vamikibart for uveitic macular edema: week 52 efficacy and safety results from the phase 3 MEERKAT and SANDCAT trials [session: RET22: section XIX: clinical trial updates – part II]. Session presented at: American Academy of Ophthalmology 2026 Annual Meeting; October 9-12, 2026; New Orleans, LA.
Campochiaro PA, Avery R, Brown DM, et al. Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study. Lancet. 2024;403(10436):1563-1573. doi:10.1016/S0140-6736(24)00310-6
Moshfeghi DM. Phase 3 trial of OTX-TKI (SOL-1) for wet AMD [session: RET12: section X: clinical trial updates, part I]. Session presented at: American Academy of Ophthalmology 2026 Annual Meeting; October 9-12, 2026; New Orleans, LA.
Regillo CD. First-time results of the LUGANO pivotal phase 3 trial: bioerodible EYP-1901 in wet AMD [session: RET12: section X: clinical trial updates, part I]. Session presented at: American Academy of Ophthalmology 2026 Annual Meeting; October 9-12, 2026; New Orleans, LA.
Wykoff CC. The DAYBREAK phase 3, randomized, double-masked, 3-arm, clinical trial: first-time results of tarcocimab vs tabirafusp vs aflibercept for neovascular AMD relevance [session: RET12: section X: clinical trial updates, part I]. Session presented at: American Academy of Ophthalmology 2026 Annual Meeting; October 9-12, 2026; New Orleans, LA.
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