Oncology
Gastroenteropancreatic Neuroendocrine Tumors
Conference Reporter® Podcast: Next-Wave Radiopharmaceuticals and Theranostic Frontiers in Gastroenteropancreatic Neuroendocrine Tumors
Investigators at the 2026 Society of Nuclear Medicine & Molecular Imaging (SNMMI) Annual Meeting presented data from several studies involving next-generation agents and emerging technologies. Such efforts reflect the continued pursuit of theranostic advancements in oncology generally and in gastroenteropancreatic neuroendocrine tumors in particular. Simron Singh, MD, MPH, FRCPC, discusses these data in today’s podcast.
Following these presentations, featured expert Simron Singh, MD, MPH, FRCPC, was interviewed by Conference Reporter Editor-in-Chief Tom Iarocci, MD. Clinical perspectives from Dr Singh on these findings are presented here.
Clinical Trials.gov. Testing the effectiveness of an anti-cancer drug, triapine, when used with targeted radiation-based treatment (lutetium Lu 177 dotatate), compared to lutetium Lu 177 dotatate alone for metastatic neuroendocrine tumors. Updated May 13, 2026. Accessed June 12, 2026. https://clinicaltrials.gov/study/NCT05724108
Corbett V, Gupta G, Chauhan A. PRRT for well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Endocr Relat Cancer. 2026;33(3):e250495. doi:10.1530/ERC-25-0495
Deshayes E, Assenat E, Meignant L, Bardiès M, Santoro L, Gourgou S. A prospective, randomized, phase II study to assess the schemas of retreatment with Lutathera® in patients with new progression of an intestinal, well-differentiated neuroendocrine tumor (ReLUTH). BMC Cancer. 2022;22(1):1346. doi:10.1186/s12885-022-10443-4
Guillaume N, Chirindel A, Kaul F, et al. [61Cu]Cu-NODAGA-LM3 versus [68Ga]Ga-DOTATOC in the same patients with neuroendocrine tumors: results of the phase I/II COPPER-PET-in-NET trial [abstract 261595] [session: SS15: Neuroendocrine oncology—clinical diagnosis and therapy]. Abstract presented at: 2026 Society of Nuclear Medicine & Molecular Imaging Annual Meeting; May 30-June 2, 2026; Los Angeles, CA.
Hardiansyah D, Kaiser L, Costa PF, et al. Accurate single-time-point dosimetry of [177Lu]Lu-edotreotide using non-linear mixed-effects modeling: results from the COMPETE phase 3 trial [abstract 261100] [session: Science pavilion]. Poster presented at: 2026 Society of Nuclear Medicine & Molecular Imaging Annual Meeting; May 30-June 2, 2026; Los Angeles, CA.
Nicolas GP, Lafont MA, McDougall L, et al. First-in-human administration of [61Cu]Cu-NODAGA-LM3 and head-to-head comparison with [68Ga]Ga-DOTA-TOC PET/CT as part of the phase I/II COPPER PET in NET study. Eur J Nucl Med Mol Imaging. 2026;53(2):710-712. doi:10.1007/s00259-025-07301-3
Perrone E, Ghai K, Eismant A, et al. Beyond β-peptide receptor radionuclide therapy (PRRT) with somatostatin receptor (SSTR) agonists: real-world outcomes of SSTR antagonist α-PRRT in heavily pretreated G3 neuroendocrine neoplasms [abstract 261577] [session: SS15: Neuroendocrine oncology—clinical diagnosis and therapy]. Abstract presented at: 2026 Society of Nuclear Medicine & Molecular Imaging Annual Meeting; May 30-June 2, 2026; Los Angeles, CA.
Sgouros G, Ulaner GA, He B, et al. Dosimetry results from the phase 1b/3 ACTION-1 trial of [225AC]Ac-DOTATATE (RYZ101) in patients with somatostatin receptor-expressing, well-differentiated GEP-NETs. J Nucl Med. Published online June 4, 2026. doi:10.2967/jnumed.125.270573
Sgouros G, Ulaner G, Delie T, et al. 225Ac-DOTATATE dosimetry results from part 1 of the ACTION-1 trial. J Nucl Med. 2023;64(suppl 1):P129.
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