Nephrology

IgAN

Expert Roundtables Podcast: Advances and Future Directions in IgA Nephropathy Research

expert roundtables by Richard Lafayette, MD, FACP; Carla M. Nester, MD, MSA, FASN; Jai Radhakrishnan, MD, MS

Overview

<p>Clinical research has led to the US Food and Drug Administration (FDA) approval of a handful of effective targeted therapies for IgA nephropathy (IgAN). Research on other agents is ongoing, and there is hope that clinical outcomes can be further improved with combination therapies. Our featured experts review recent and ongoing research and their potential impact on the future of IgAN.</p>

References

Barratt J, Lafayette RA, Floege J. Therapy of IgA nephropathy: time for a paradigm change. Front Med (Lausanne). 2024;11:1461879. doi:10.3389/fmed.2024.1461879

Cheung CK, Alexander S, Reich HN, Selvaskandan H, Zhang H, Barratt J. The pathogenesis of IgA nephropathy and implications for treatment. Nat Rev Nephrol. 2024 Sep 4;10.1038/s41581-024-00885-3. doi:10.1038/s41581-024-00885-3

Hunter-Dickson M, Wong MG. The role of endothelin receptor antagonists in IgA nephropathy. Nephrology (Carlton). 2024;29(suppl 2):30-33. doi:10.1111/nep.14364

Lim RS, Yeo SC, Barratt J, Rizk DV. An update on current therapeutic options in IgA nephropathy. J Clin Med. 2024;13(4):947. doi:10.3390/jcm13040947

Selvaskandan H, Barratt J, Cheung CK. Novel treatment paradigms: primary IgA nephropathy. Kidney Int Rep. 2023;9(2):203-213. doi:10.1016/j.ekir.2023.11.026

Selvaskandan H, Jhaveri KD, Rizk DV. Primary IgA nephropathy: new insights and emerging therapies. Adv Kidney Dis Health. 2024;31(3):180-193. doi:10.1053/j.akdh.2024.04.002

Suzuki Y. B cell targeting in IgA nephropathy. Nephrology (Carlton). 2024;29(suppl 2):39-43. doi:10.1111/nep.14367

Profile

Richard Lafayette, MD, FACP

Professor of Medicine (Nephrology)
Director
Stanford Glomerular Disease Center
Stanford University Medical Center
Stanford, CA

Profile

Carla M. Nester, MD, MSA, FASN

Jean Robillard Professor of Pediatric Nephrology
Division Director of Pediatric Nephrology, Dialysis, and Transplantation
University of Iowa Stead Family Children's Hospital
Iowa City, IA