Neurology

Relapsing Multiple Sclerosis

Expert Roundtables Podcast: Emerging Therapeutic Targets for Relapsing Multiple Sclerosis

expert roundtables by Robert A. Bermel, MD, MBA; Fred D. Lublin, MD; Robert T. Naismith, MD

Overview

<p>As the neurobiology of relapsing multiple sclerosis and its underlying pathophysiologic mechanisms, such as demyelination, neuroinflammation, and neuroaxonal damage, continue to be elucidated, emerging therapeutic targets include remyelination and the modulation of central nervous system–bound inflammation and neurodegeneration. Our featured experts talk about these therapeutic targets in this Expert Roundtables conversation.</p> <p> </p> <p><iframe title="Expert Perspectives® in Relapsing Multiple Sclerosis Podcast" width="500" height="281" src="https://www.youtube.com/embed/JVcenLEEiPg?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>

References

Bsteh G, Dal Bianco A, Zrzavy T, Berger T. Novel and emerging treatments to target pathophysiological mechanisms in various phenotypes of multiple sclerosis. Pharmacol Rev. 2024;76(4):564-578. doi:10.1124/pharmrev.124.001073

Eva L, Pleș H, Covache-Busuioc RA, et al. A comprehensive review on neuroimmunology: insights from multiple sclerosis to future therapeutic developments. Biomedicines. 2023;11(9):2489. doi:10.3390/biomedicines11092489

Mwema A, Muccioli GG, des Rieux A. Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis. J Control Release. 2023;364:435-457. doi:10.1016/j.jconrel.2023.10.052

Olejnik P, Roszkowska Z, Adamus S, Kasarełło K. Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects. Pharmacol Rep. 2024;76(5):926-943. doi:10.1007/s43440-024-00642-0

Piehl F. Current and emerging disease-modulatory therapies and treatment targets for multiple sclerosis. J Intern Med. 2021;289(6):771-791. doi:10.1111/joim.13215

Yang JH, Rempe T, Whitmire N, Dunn-Pirio A, Graves JS. Therapeutic advances in multiple sclerosis. Front Neurol. 2022;13:824926. doi:10.3389/neur.2022.824926

Profile

Robert A. Bermel, MD, MBA

Staff Neurologist and Director
Mellen Center for Multiple Sclerosis
Cleveland Clinic
Cleveland, OH

Profile

Fred D. Lublin, MD

Saunders Family Professor of Neurology
Director, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis
Icahn School of Medicine at Mount Sinai
New York, NY

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Robert T. Naismith, MD

Professor of Neurology
Clinic Director, John L. Trotter Multiple Sclerosis Center
Director, Clinical Trials in Multiple Sclerosis and Neuroimmunology
Washington University
St. Louis, MO