Rheumatology

Rheumatoid Arthritis

Expert Roundtables Podcast: Research Directions in Rheumatoid Arthritis

expert roundtables by Eric M. Ruderman, MD; Michael E. Weinblatt, MD; Michael H. Weisman, MD

Overview

<p>Patients with rheumatoid arthritis (RA) have an outlook today that is greatly improved relative to decades past. Ongoing research focuses on RA prevention, precision medicine, and the identification of biomarkers to guide treatment decisions. Additionally, the heart and lungs continue to be of great interest in RA. Join 3 respected rheumatologists as they explore the emerging frontier in RA research.</p>

References

Brewer RC, Lanz TV, Hale CR, et al. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci Transl Med. 2023;15(684):eabq8476. doi:10.1126/scitranslmed.abq8476

Dunlap G, Wagner A, Meednu N, et al. Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium. Nat Commun. 2024;15(1):4991. doi:10.1038/s41467-024-49186-0

Holers VM, Demoruelle KM, Buckner JH, et al. Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis. Nat Rev Rheumatol. 2024;20(10):601-613. doi:10.1038/s41584-024-01154-0

Kimbrough BA, Crowson CS, Davis JM 3rd, Matteson EL, Myasoedova E. Decline in incidence of extra-articular manifestations of rheumatoid arthritis: a population-based cohort study. Arthritis Care Res (Hoboken). 2024;76(4):454-462. doi:10.1002/acr.25231

Koduri G, Solomon JJ. Identification, monitoring, and management of rheumatoid arthritis–associated interstitial lung disease. Arthritis Rheumatol. 2023;75(12):2067-2077. doi:10.1002/art.42640

Németh T, Nagy G, Pap T. Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go? Ann Rheum Dis. 2022;81(8):1055-1064. doi:10.1136/annrheumdis-2021-222021

Orange DE, Yao V, Sawicka K, et al. RNA identification of PRIME cells predicting rheumatoid arthritis flares. N Engl J Med. 2020;383(3):218-228. doi:10.1056/NEJMoa2004114

Weber B, Weisenfeld D, Massarotti E, et al. Interplay between systemic inflammation, myocardial injury, and coronary microvascular dysfunction in rheumatoid arthritis: results from the LiiRA study. J Am Heart Assoc. 2024;13(9):e030387. doi:10.1161/JAHA.123.030387