Rheumatology

Rheumatoid Arthritis

PODCAST: Precision Rheumatology and Patient-Centered Treatment of Rheumatoid Arthritis

patient care perspectives by Eric M. Ruderman, MD

Overview

The use of precision medicine may revolutionize the management of rheumatoid arthritis (RA). By combining insights from synovial biopsy findings with artificial intelligence analysis of blood work, precision medicine is allowing for more personalized care that can encompass the management of not only the patient’s inflammatory symptoms but also pain from other sources that may be resistant to traditional therapies.

“. . . in precision rheumatology, I can get a biopsy of the synovial tissue to gain insights into which of the available drugs is most likely to work for my patient with RA. . . . The hope is that we will learn from the results of the biopsy and then also look to the results of the patient's blood work or other biomarkers for more information.”

— Eric M. Ruderman, MD

References

Bhamidipati K, Wei K. Precision medicine in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2022;36(1):101742. doi:10.1016/j.berh.2022.101742

Creagh AP, Hamy V, Yuan H, et al. Digital health technologies and machine learning augment patient reported outcomes to remotely characterise rheumatoid arthritis. NPJ Digit Med. 2024;7(1):33. doi:10.1038/s41746-024-01013-y

Das D, Choy E. Non-inflammatory pain in inflammatory arthritis. Rheumatology (Oxford). 2023;62(7):2360-2365. doi:10.1093/rheumatology/keac671

Hamy V, Llop C, Yee CW, et al. Patient-centric assessment of rheumatoid arthritis using a smartwatch and bespoke mobile app in a clinical setting. Sci Rep. 2023;13(1):18311. doi:10.1038/s41598-023-45387-7

Jonsson AH. Synovial tissue insights into heterogeneity of rheumatoid arthritis. Curr Rheumatol Rep. 2024;26(3):81-88. doi:10.1007/s11926-023-01129-2

Perera J, Delrosso CA, Nerviani A, Pitzalis C. Clinical phenotypes, serological biomarkers, and synovial features defining seropositive and seronegative rheumatoid arthritis: a literature review. Cells. 2024;13(9):743. doi:10.3390/cells13090743