Rheumatology

Rheumatoid Arthritis

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Expert Roundtables Podcast: Research Directions in Rheumatoid Arthritis

expert roundtables by Eric M. Ruderman, MD; Michael E. Weinblatt, MD; Michael H. Weisman, MD
Overview

Patients with rheumatoid arthritis (RA) have an outlook today that is greatly improved relative to decades past. Ongoing research focuses on RA prevention, precision medicine, and the identification of biomarkers to guide treatment decisions. Additionally, the heart and lungs continue to be of great interest in RA. Join 3 respected rheumatologists as they explore the emerging frontier in RA research.

References

Brewer RC, Lanz TV, Hale CR, et al. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci Transl Med. 2023;15(684):eabq8476. doi:10.1126/scitranslmed.abq8476

 

Dunlap G, Wagner A, Meednu N, et al. Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium. Nat Commun. 2024;15(1):4991. doi:10.1038/s41467-024-49186-0

 

Holers VM, Demoruelle KM, Buckner JH, et al. Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis. Nat Rev Rheumatol. 2024;20(10):601-613. doi:10.1038/s41584-024-01154-0

 

Kimbrough BA, Crowson CS, Davis JM 3rd, Matteson EL, Myasoedova E. Decline in incidence of extra-articular manifestations of rheumatoid arthritis: a population-based cohort study. Arthritis Care Res (Hoboken). 2024;76(4):454-462. doi:10.1002/acr.25231

 

Koduri G, Solomon JJ. Identification, monitoring, and management of rheumatoid arthritis–associated interstitial lung disease. Arthritis Rheumatol. 2023;75(12):2067-2077. doi:10.1002/art.42640

 

Németh T, Nagy G, Pap T. Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go? Ann Rheum Dis. 2022;81(8):1055-1064. doi:10.1136/annrheumdis-2021-222021

 

Orange DE, Yao V, Sawicka K, et al. RNA identification of PRIME cells predicting rheumatoid arthritis flares. N Engl J Med. 2020;383(3):218-228. doi:10.1056/NEJMoa2004114

 

Weber B, Weisenfeld D, Massarotti E, et al. Interplay between systemic inflammation, myocardial injury, and coronary microvascular dysfunction in rheumatoid arthritis: results from the LiiRA study. J Am Heart Assoc. 2024;13(9):e030387. doi:10.1161/JAHA.123.030387

Eric M. Ruderman, MD

Professor of Medicine
Associate Chief for Clinical Affairs
Division of Rheumatology
Northwestern University Feinberg School of Medicine
Chicago, IL

Michael E. Weinblatt, MD

    R. Bruce and Joan M. Mickey Distinguished Chair in Rheumatology
    Brigham and Women’s Hospital
    John and Eileen K. Riedman Professor of Medicine
    Harvard Medical School
    Boston, MA

Michael H. Weisman, MD

    Adjunct Professor of Medicine, Stanford University School of Medicine Stanford, CA
    Distinguished Professor of Medicine Emeritus, David Geffen School of Medicine at UCLA
    Professor of Medicine Emeritus, Cedars-Sinai Medical Center
    Los Angeles, CA
    Professor of Medicine Emeritus, UC San Diego School of Medicine
    San Diego, CA
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