Infectious Diseases

COVID-19 Prevention

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Patient Care Perspectives Podcast: Assessing Exposure Risk and Discussing Early Prevention Options With Patients

patient care perspectives by Anthony Cheng, MD, MBA
Overview

For patients with known or possible COVID-19 exposure, Anthony Cheng, MD, MBA, emphasizes a practical risk-based approach that starts with clarifying the likelihood of transmission and the likelihood of progression to severe illness. In this podcast, Dr Cheng discusses how primary care clinicians can frame exposure risk, use serial rapid antigen testing when results will guide action, reinforce prevention measures during ongoing household exposure, and distinguish postexposure prophylaxis from treatment once a patient tests positive for COVID-19.

 

References

Hayden FG, Shinkai M, Clark TW, et al; SCORPIO-PEP Study Team. Ensitrelvir for Covid-19 postexposure prophylaxis in household contacts. N Engl J Med. 2026;394(19):1905-1915. doi:10.1056/NEJMoa2509306

 

Marzolini C, Kuritzkes DR, Marra F, et al. Recommendations for the management of drug-drug interactions between the COVID-19 antiviral nirmatrelvir/ritonavir (Paxlovid) and comedications. Clin Pharmacol Ther. 2022;112(6):1191-1200. doi:10.1002/cpt.2646

 

Shumaker AH, Bhimraj A, Bedimo R, et al. 2025 clinical practice guideline update by the Infectious Diseases Society of America on the treatment and management of COVID-19: antiviral treatment for mild to moderate COVID-19 in adults. Clin Infect Dis. 2026;82(suppl 3):i1-i17. doi:10.1093/cid/ciaf680

 

Soni A, Herbert C, Lin H, et al. Performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection: a prospective cohort study. Ann Intern Med. 2023;176(7):975-982. doi:10.7326/M23-0385

Anthony Cheng, MD, MBA

Associate Chief Clinical Transformation Officer
Office of Care Transformation and Innovation
Associate Professor
Department of Family Medicine
Oregon Health & Science University
Portland, OR

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