Combination therapies of a low-dose steroid with a second- or third-line treatment option may be useful in patients with chronic ITP. When we are talking about chronic ITP, we are not talking about rescue therapy. We are talking about what I call maintenance therapy, and trying to find a long-term strategy for maintaining a hemostatic platelet count that is both effective and tolerable for the patient. I would never want to use high doses of steroids over the long term because of cumulative toxicity. Therefore, one of my major treatment goals is to get patients either off of steroids entirely or to get them on very low doses. But, I do think that there is a role for using low-dose steroids, and by that I mean prednisone 5 mg per day or less in combination with other therapies to maintain a safe platelet count. I have had a number of patients, for example, who did not respond well to a TPO-RA alone, but, when we combined it with low-dose prednisone (maybe 5 mg per day or 5 mg every other day), that combination achieved a good and sustainable response. I do think that there’s a role for combination therapy with corticosteroids in select patients, but the key is that it has to be a low dose.