Oncology

PSMA+ mCRPC

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Expert Roundtables Podcast: Redefining Prostate Cancer in the Era of Advanced Diagnostics

expert roundtables by Neeraj Agarwal, MD, FASCO; Peter R. Carroll, MD, MPH; William K. Oh, MD
Overview

Advanced diagnostic tools, such as prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) scans, have revolutionized the diagnosis of prostate cancer. However, they also pose challenges for clinicians making treatment decisions in patients with low-risk disease. In this podcast, prostate cancer experts Neeraj Agarwal, MD, FASCO, Peter R. Carroll, MD, MPH, and William K. Oh, MD, discuss the importance of redefining prostate cancer in the era of advanced diagnostics.

 

References

Armstrong AJ, Morris MJ, Abida W, et al; PCWG4 Writing Group. Trial design and objectives for patients with prostate cancer: recommendations from the Prostate Cancer Working Group 4. J Clin Oncol. 2026;44(13):1249-1265. doi:10.1200/JCO-25-02834

 

Carlsson SV, Carroll PR, Hamdy FC. Reevaluating the definition of clinically significant prostate cancer as Grade Groups 2 to 5: an imperative for improved risk stratification. J Urol. 2025;213(2):238-241. doi:10.1097/JU.0000000000004253

 

ClinicalTrials.gov. A study of an intermittent ADT approach with apalutamide monotherapy in participants with mCSPC (LIBERTAS). Updated September 25, 2026. Accessed October 26, 2026. https://clinicaltrials.gov/study/NCT05884398

 

ClinicalTrials.gov. Intermittent androgen deprivation therapy in the era of AR pathway inhibitors. Updated September 19, 2025. Accessed October 26, 2026. https://clinicaltrials.gov/study/NCT05974774

 

ClinicalTrials.gov. Safety and efficacy study of enzalutamide plus leuprolide in patients with nonmetastatic prostate cancer (EMBARK). Updated October 26, 2026. Accessed October 26, 2026. https://clinicaltrials.gov/study/NCT02319837

 

Crawford ED, Petrylak D. Castration-resistant prostate cancer: descriptive yet pejorative? J Clin Oncol. 2010;28(23):e408. doi:10.1200/JCO.2010.28.7664

 

Fizazi K, Clarke NW, De Santis M, et al; CAPItello-281 Study Group. Capivasertib plus abiraterone in PTEN-deficient metastatic hormone-sensitive prostate cancer: CAPItello-281 phase III study. Ann Oncol. 2026;37(1):53-68. doi:10.1016/j.annonc.2025.10.004

 

Oh WK, Agarwal N, Bryce A, et al. What’s in a name? Why words matter in advanced prostate cancer. Eur Urol. 2025;87(2):101-103. doi:10.1016/j.eururo.2024.10.017

 

Pezaro CJ, Omlin A, Mastris K, et al; ANZUP Consumer Advisory Panel. Precision, complexity and stigma in advanced prostate cancer terminology: it is time to move away from ‘castration-resistant’ prostate cancer. Ann Oncol. 2017;28(8):1692-1694. doi:10.1093/annonc/mdx312

Neeraj Agarwal, MD, FASCO

Medical Oncologist and Faculty
Dana-Farber Cancer Institute
Codirector
Dana-Farber/Harvard Cancer Consortium Prostate Cancer Program
Boston, MA

Peter R. Carroll, MD, MPH

Ken and Donna Derr – Chevron Distinguished Professor
Department of Urology
UCSF Helen Diller Family Comprehensive Cancer Center
University of California, San Francisco
San Francisco, CA

William K. Oh, MD

Director of Precision Medicine, Yale Cancer Center
Professor of Medicine, Yale School of Medicine
New Haven, CT
The Jean and David W. Wallace Medical Director
Smilow Cancer Hospital at Greenwich
Greenwich, CT

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