Is there a way that we can start with a lower dose of the regimen or lower the dose in patients who experience side effects? With FOLFIRINOX, in the United States, I would say a lot of people would start the treatment without the bolus 5-fluorouracil (5-FU). Trying to not use bolus 5-FU is considered to be one way of trying to give the treatment with a lesser chance of having some of the hematologic side effects, and also the gastrointestinal (GI) toxicities. However, different clinicians will also adopt different ways of trying to modify FOLFIRINOX treatment. For example, some people will start the FOLFIRINOX treatment with 20% dose reductions across the board. With gemcitabine + nab-paclitaxel, when we are trying to handle toxicity, one way is to try to give it every 2 weeks. You can either give it the usual way, which is 3 weeks on and 1 week off, but you can also give it every other week. In my practice and my experience, with patients who are older and may have borderline performance status, I sometimes start with every other week of treatment. In some of those patients, I might even start with every other week and a 20% dose reduction of both drugs. In patients who have informal toxicity on gemcitabine + nab-paclitaxel, I may also switch it up, providing a better chance for the patient to recover from the side effects between treatment. These are some things that clinicians can do. You can either start with a modified treatment regimen or modify the regimen as the patient develops side effects.