Hematology

Paroxysmal Nocturnal Hemoglobinuria

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Expert Roundtables Podcast: Management of Thrombosis Risk in Paroxysmal Nocturnal Hemoglobinuria

expert perspectives by David Dingli, MD, PhD; Caroline Piatek, MD; Jamile M. Shammo, MD, FASCP, FACP
Overview
<p>Thrombosis remains a leading cause of morbidity and mortality in paroxysmal nocturnal hemoglobinuria (PNH). Complement inhibitors are the cornerstone of treatment for PNH, significantly lowering the risk of thrombotic events. As noted by our experts in today’s podcast, anticoagulation continues to play a critical role, particularly in the secondary prevention and management of acute thrombosis.</p> <p> </p> <p><iframe title="Expert Perspectives® in PNH Podcast 2025" width="500" height="281" src="https://www.youtube.com/embed/pnv4N7VVqW0?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></p>
References

Chen Y, Meng X, Wang Y, Liu C, Fu R. Several implications for the pathogenesis and treatment of thrombosis in PNH patients according to multiomics analysis. J Transl Med. 2024;22(1):129. doi:10.1186/s12967-024-04936-y

 

Kokoris S, Polyviou A, Evangelidis P, et al. Thrombosis in paroxysmal nocturnal hemoglobinuria (PNH): from pathogenesis to treatment. Int J Mol Sci. 2024;25(22):12104. doi:10.3390/ijms252212104.

 

Szer J. Thrombosis on PNH: largely gone, but not forgotten. Blood. 2024;144(2):125-126. doi:10.1182/blood.2024024660.

David Dingli, MD, PhD

    Professor of Medicine
    Mayo Clinic College of Medicine and Science
    Consultant, Division of Hematology
    Director, Bone Marrow Transplant Program
    Mayo Clinic
    Rochester, MN

Caroline Piatek, MD

Associate Professor of Clinical Medicine
Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases
USC Norris Comprehensive Cancer Center
Keck School of Medicine of USC
Los Angeles, CA

Jamile M. Shammo, MD, FASCP, FACP

Dr. Marjorie C. Barnett - Dr. Hau C. Kwaan Professor
Director, Bone Marrow Failure Program
Division of Hematology and Oncology
Northwestern University Feinberg School of Medicine
Chicago, IL

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